It’s Like A Pulse Oximeter, But It Measures Carbon Monoxide

A CO-oximeter is a device that measures the oxygen carrying state of hemoglobin in a blood specimen, including oxygen-carrying hemoglobin (O2Hb), non-oxygen-carrying but normal hemoglobin (HHb) (formerly, but incorrectly, referred to as ‘reduced’ hemoglobin), as well as the dyshemoglobins such as carboxyhemoglobin (COHb) and methemoglobin (MetHb). The use of ‘CO’ rather than ‘Co’ or ‘co’ is more appropriate since this designation represents a device that measures carbon monoxide (CO) bound to hemoglobin, as distinguished from simple oximetry which measures hemoglobin bound to molecular oxygen—O2Hb—or hemoglobin capable of binding to molecular oxygen—HHb. Simpler oximeters may report oxygen saturation alone, i.e. the ratio of oxyhemoglobin to total ‘bindable’ hemoglobin (i.e. oxyhemoglobin + deoxyhemoglobin-HHb). CO-oximetry is useful in defining the causes for hypoxemia, or hypoxia, (oxygen deficiency at the tissue level).

A CO-oximeter measures the absorption of light passing through blood from few as two or three wavelengths of light to several dozens of wavelengths, in order to distinguish oxyhemoglobin, and deoxyhemoglobin (formerly called ‘reduced’ hemoglobin), and thus determine the oxyhemoglobin saturation (the percentage of oxygenated hemoglobin compared to the total amount of available hemoglobin (Hb)). Measurement of greater numbers of wavelengths enables the instrument to distinguish between these and carboxyhemoglobin,-COHb, methemoglobin -metHb, other hemoglobin moieties and ‘background’ light-absorbing species. Traditionally, measurement is made from arterial blood processed in a specific device designed to be able to measure proportions of multiple components of several hemoglobin moieties using multi-wavelength spectrophotometry and complex, but straightforward internal computations. While these units still are in wide use, blood gas analyzers with integral CO-oximetry modules have also been developed and successfully marketed by several manufacturers. More recently, some ‘pulse’ or more precisely ‘peripheral’ oximeters have made it possible to estimate carboxyhemoglobin with non-invasive technology similar to a simple (peripheral) pulse oximeter. In contrast, the use of a standard or simple pulse oximeter is not effective in the diagnosis of CO poisoning as patients who have carbon monoxide poisoning may have a normal oxygen saturation reading on a pulse oximeter.